The city suffered a large fire in the night from 22 October to 23 October 1576. The fire started in brewery het Ankertje, near the weighhouse at the Spaarne, which was used by mercenaries as a guarding place. When they were warming themselves at a fire it got out of control. The fire was spotted by farmers, who sailed their ships on the river. However, the soldiers turned down all help, saying that they would put out the fire themselves. This failed, and the fire destroyed almost 500 buildings, among them St-Gangolf’s church and St-Elisabeth’s hospital.